Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants

Taniguchi-Takizawa, T; Kato, H; Shimizu, M; Yamazaki, H

Taniguchi-Takizawa, T (corresponding author), Mitsubishi Tanabe Pharma Corp, Discovery Technol Labs, Sohyaku Innovat Res Div, Fujisawa, Kanagawa 2518555, Japan.; Yamazaki, H (corresponding author), Showa Pharmaceut Univ, 3-3165 Higashitamagawa Gakuen, Machida, Tokyo 1948543, Japan.

CURRENT DRUG METABOLISM, 2021; 22 (3): 208

Abstract

Aims: Base dissociation constants of 30 model chemicals were investigated to constitute potential determinant factors predicting the contributions of ......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索