The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

Oh, M; Jang, SY; Lee, JY; Kim, JW; Jung, Y; Kim, J; Seo, J; Han, TS; Jang, E; Son, HY; Kim, D; Kim, MW; Park, JS; Song, KH; Oh, KJ; Kim, WK; Bae, KH; Huh, YM; Kim, SH; Kim, D; Han, BS; Lee, SC; Hwang, GS; Lee, EW

Han, BS (通讯作者),Korea Res Inst Biosci & Biotechnol KRIBB, Biodefense Res Ctr, Daejeon 34141, South Korea.;Hwang, GS (通讯作者),Korea Basic Sci Inst, Western Seoul Ctr, Integrated Metabol Res Grp, Seoul 03759, South Korea.;Han, BS; Lee, SC; Lee, EW (通讯作者),Korea Res Inst Biosci & Biotechnol KRIBB, Metab Regulat Res Ctr, Daejeon 34141, South Korea.;Han, BS; Lee, EW (通讯作者),Univ Sci & Technol UST, Dept Funct Genom, Daejeon 34141, South Korea.;Hwang, GS (通讯作者),Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea.;Lee, EW (通讯作者),Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) co......

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