Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis

Wu, Q; Sun, LL; Hu, XM; Wang, XM; Xu, F; Chen, B; Liang, XY; Xia, JL; Wang, PC; Aibara, D; Zhang, SF; Zeng, GY; Yun, CY; Yan, Y; Zhu, YC; Bustin, M; Zhang, SY; Gonzalez, FJ; Jiang, CT

Jiang, CT (corresponding author), Peking Univ, Dept Physiol & Pathophysiol, Physiol Bldg,Room 324,38 Xueyuan Rd, Beijing 100191, Peoples R China.; Gonzalez, FJ (corresponding author), NCI, NIH, Bldg 37,Room 3112,9000 Rockville Pike, Bethesda, MD 20892 USA.; Zhang, SY (corresponding author), Peking Union Med Coll Hosp, Dept Cardiol, Acad Bldg,Room 901,1 Shuaifuyuan, Beijing 100730, Peoples R China.

JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (9):

Abstract

Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role......

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