G(i)- and G(s)-coupled GPCRs show different modes of G-protein binding

Van Eps, N; Altenbach, C; Caro, LN; Latorraca, NR; Hollingsworth, SA; Dror, RO; Ernst, OP; Hubbell, WL

Ernst, OP (reprint author), Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.; Hubbell, WL (reprint author), Univ Calif Los Angeles, Stein Eye Inst, Los Angeles, CA 90095 USA.; Hubbell, WL (reprint author), Univ Calif Los Angeles, Dept Chem & Bioch

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (10): 2383

Abstract

More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin ......

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