mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

Beaumatin, F; O'Prey, J; Barthet, VJA; Zunino, B; Parvy, JP; Bachmann, AM; O'Prey, M; Kania, E; Gonzalez, PS; Macintosh, R; Lao, LY; Nixon, C; Lopez, J; Long, JS; Tait, SWG; Ryan, KM

Ryan, KM (reprint author), Canc Res UK Beatson Inst, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland.; Ryan, KM (reprint author), Univ Glasgow, Inst Canc Sci, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland.

MOLECULAR CELL, 2019; 76 (1): 163

Abstract

Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索