The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

O'Connor, RS; Guo, LL; Ghassemi, S; Snyder, NW; Worth, AJ; Weng, L; Kam, Y; Philipson, B; Trefely, S; Nunez-Cruz, S; Blair, IA; June, CH; Milone, MC

Milone, MC (reprint author), Univ Penn, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA.; Milone, MC (reprint author), Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine pa......

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