CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

Lin, YH; Zhao, YL; Chen, MG; Li, ZS; Liu, Q; Chen, J; Ding, Y; Ding, CY; Ding, Y; Qi, CL; Zheng, LY; Li, JC; Zhang, RX; Zhou, J; Wang, LJ; Zhang, QQ

Wang, LJ; Zhang, QQ (通讯作者)，Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Peoples R China.;Zhou, J (通讯作者)，Univ Texas Med Branch, Dept Pharmacol & Toxicol, Chem Biol Program, Galveston, TX 77555 USA.

BMC CANCER, 2023; 23 (1):

Abstract

BackgroundB-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among......

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