Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type

Ji, JX; Cochrane, DR; Tessier-Cloutier, B; Chen, SY; Ho, G; Pathak, KV; Alcazar, IN; Farnell, D; Leung, S; Cheng, A; Chow, C; Colborne, S; Negri, GL; Kommoss, F; Karnezis, A; Morin, GB; McAlpine, JN; Gilks, CB; Weissman, BE; Trent, JM; Hoang, L; Pirrotte, P; Wang, YM; Huntsman, DG

Huntsman, DG (corresponding author), Univ British Columbia, BC Canc Res Ctr, 675 West 10th Ave, Vancouver, BC V5Z 4E6, Canada.

CLINICAL CANCER RESEARCH, 2020; 26 (16): 4402

Abstract

Purpose: Many rare ovarian cancer subtypes, such as small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT), have poor prognosis due to their a......

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