The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p

Chiu, YS; Bamodu, OA; Fong, IH; Lee, WH; Lin, CC; Lu, CH; Yeh, CT

Yeh, CT (corresponding author), Taipei Med Univ, Shuang Ho Hosp, Dept Med Res & Educ, New Taipei 23561, Taiwan.; Lee, WH (corresponding author), Taipei Med Univ, Shuang Ho Hosp, Dept Pathol, New Taipei, Taiwan.

BONE, 2021; 151 ():

Abstract

Background: Osteoarthritis (OA), a common articular bone degenerative disease, is exacerbated by proinflammatory cytokine signaling. Mounting evidence......

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