An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

Ai, YW; He, HB; Chen, PH; Yan, B; Zhang, WB; Ding, ZC; Li, DR; Chen, J; Ma, Y; Cao, Y; Zhu, J; Li, JJ; Ou, JJ; Du, S; Wang, XD; Ma, JZ; Gao, SH; Qi, XB

Ai, YW; Ma, JZ (corresponding author), Northeast Forestry Univ, Coll Wildlife & Protected Area, Hexing Rd, Harbin 150040, Peoples R China.; Ai, YW; Qi, XB (corresponding author), Natl Inst Biol Sci, 7 Sci Pk Rd,Zhongguancun Life Sci Pk, Beijing 102206, Peoples R China.; Ai, YW; Qi, XB (corresponding author), Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing, Peoples R China.; Gao, SH (corresponding author), East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

The promotion of apoptosis in tumor cells is a popular strategy for developing anti-cancer drugs. Here, we demonstrate that the plant indole alkaloid ......

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