NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Nai, A; Lidonnici, MR; Federico, G; Pettinato, M; Olivari, V; Carrillo, F; Crich, SG; Ferrari, G; Camaschella, C; Silvestri, L; Carlomagno, F

Silvestri, L (corresponding author), Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy.; Silvestri, L (corresponding author), Univ Vita Salute San Raffaele, Milan, Italy.; Carlomagno, F (corresponding author), Univ Naples Federico II, Dept Mol Med & Med Biotechnol DMMBM, Naples, Italy.; Carlomagno, F (corresponding author), CNR, Inst Endocrinol & Expt Oncol IEOS, Naples, Italy.

HAEMATOLOGICA, 2021; 106 (3): 795

Abstract

Nuclear receptor coactivator 4 (NCOA4) promotes ferritin degradation and Ncoa4-ko mice in a C57BL/6 background show microcytosis and mild anemia, aggr......

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