RNA modifications can affect RNase H1-mediated PS-ASO activity

Lacy, KAD; Liang, XH; Zhang, LD; Crooke, ST

Lacy, KAD (通讯作者),Core Antisense Res Ionis Pharmaceut Inc, Carlsbad, CA 92008 USA.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2022; 28 (): 814

Abstract

Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage......

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