3,5-bis(styryl)pyrazole inhibits mitosis and induces cell death independent of BubR1 and p53 levels by depolymerizing microtubules

Batra, PJ; Kumari, A; Liao, VWY; Hibbs, DE; Groundwater, PW; Panda, D

Groundwater, PW (通讯作者)，Univ Sydney, Fac Med & Hlth, Sydney Pharm Sch, Sydney, NSW 2006, Australia.;Panda, D (通讯作者)，Natl Inst Pharmaceut Educ & Res, Mohali 160062, Punjab, India.

JOURNAL OF BIOCHEMISTRY, 2023; 174 (2): 143

Abstract

Here, we show that 3,5-bis[(1E)-2-(2,6-dichlorophenyl)ethenyl]-1H-pyrazole 2l depolymerizes microtubules and reduces the number of growing tips of mic......

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