Targeting TLR4/3 using chlorogenic acid ameliorates LPS plus POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis-MedSci.cn

Targeting TLR4/3 using chlorogenic acid ameliorates LPS plus POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Jain, S; Saha, P; Syamprasad, NP; Panda, SR; Rajdev, B; Jannu, AK; Sharma, P; Naidu, VGM

Naidu, VGM (通讯作者)，Natl Inst Pharmaceut Educ & Res Guwahati, Dept Pharmacol & Toxicol, Gauhati 781101, Assam, India.;Sharma, P (通讯作者)，Thomas Jefferson Univ, Jane & Leonard Korman Resp Inst, Sidney Kimmel Med Coll, Ctr Translat Med,Div Pulm Allergy & Crit Care Med, Philadelphia, PA 19107 USA.;Naidu, VGM (通讯作者)，Natl Inst Pharmaceut Educ & Res Guwahati, Ctr Excellence GMP Extract Facil, Dept Biotechnol, Assam, India.

Abstract

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a life-threatening condition caused due to significant pulmonary and systemic......

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Targeting TLR4/3 using chlorogenic acid ameliorates LPS plus POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

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