Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide

Roeckel, LA; Utard, V; Reiss, D; Mouheiche, J; Maurin, H; Robe, A; Audouard, E; Wood, JN; Goumon, Y; Simonin, F; Gaveriaux-Ruff, C

Gaveriaux-Ruff, C (reprint author), Inst Genet & Biol Mol & Cellulaire, Illkirch Graffenstaden, France.; Gaveriaux-Ruff, C (reprint author), Univ Strasbourg, Illkirch Graffenstaden, France.; Gaveriaux-Ruff, C (reprint author), CNRS, UMR7104, Illkirch Graf

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). T......

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