Design and linkage optimization of ursane-thalidomide-based PROTACs and identification of their targeted-degradation properties to MDM2 protein

Qi, ZW; Yang, GL; Deng, T; Wang, JM; Zhou, H; Popov, SA; Shults, EE; Wang, CZ

Qi, ZW; Wang, CZ (corresponding author), Chinese Acad Forest, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China.; Yang, GL (corresponding author), Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & By Prod Proc, Changsha 410004, Hunan, Peoples R China.

BIOORGANIC CHEMISTRY, 2021; 111 ():

Abstract

Ursolic acid (UA) is an accessible triterpenoid, widely applied in the design and synthesis of antitumor compounds. However, the mechanism of its anti......

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