HLA class-I-peptide stability mediates CD8(+) T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

Kaseke, C; Park, RJ; Singh, NK; Koundakjian, D; Bashirova, A; Beltran, WFG; Mbah, OCT; Ma, JQ; Senjobe, F; Urbach, JM; Nathan, A; Rossin, EJ; Tano-Menka, R; Khatri, A; Piechocka-Trocha, A; Waring, MT; Birnbaum, ME; Baker, BM; Carrington, M; Walker, BD; Gaiha, GD

Gaiha, GD (corresponding author), Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA.; Gaiha, GD (corresponding author), Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.

CELL REPORTS, 2021; 36 (2):

Abstract

Defining factors that governCD8(+) T cell immunodominance is critical for the rational design of vaccines for viral pathogens. Here, we assess the con......

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