Targeting BCR-ABL(+) stem/progenitor cells and BCR-ABL-T315I mutant cells by effective inhibition of the BCR-ABL-Tyr177-GRB2 complex

Chen, M; Turhan, AG; Ding, HX; Lin, QC; Meng, K; Jiang, XY

Jiang, XY (reprint author), Univ British Columbia, Terry Fox Lab, British Columbia Canc Agcy, Vancouver, BC, Canada.; Jiang, XY (reprint author), Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada.; Meng, K (reprint author), Shenogen Pharma Grp

ONCOTARGET, 2017; 8 (27): 43662

Abstract

Treatment of BCR-ABL(+) human leukemia has been significantly improved by ABL tyrosine kinase inhibitors (TKIs), but they are not curative for most pa......

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