Dynamic human MutS alpha-MutL alpha complexes compact mismatched DNA

Bradford, KC; Wilkins, H; Hao, PY; Li, ZMM; Wang, BC; Burke, D; Wu, D; Smith, AE; Spaller, L; Du, CW; Gauer, JW; Chan, E; Hsieh, P; Weninger, KR; Erie, DA

Erie, DA (corresponding author), Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.; Weninger, KR (corresponding author), North Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA.; Erie, DA (corresponding author), Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020; 117 (28): 16302

Abstract

DNA mismatch repair (MMR) corrects errors that occur during DNA replication. In humans, mutations in the proteins MutS alpha and MutL alpha that initi......

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