Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog-Thalidomide PROTACs

Kim, GY; Song, CW; Yang, YS; Lee, NR; Yoo, HS; Son, SH; Lee, SJ; Park, JS; Lee, JK; Inn, KS; Kim, NJ

Inn, KS; Kim, NJ (corresponding author), Kyung Hee Univ, Coll Pharm, 26 Kyungheedae Ro, Seoul 02447, South Korea.; Inn, KS; Kim, NJ (corresponding author), Kyung Hee Univ, Grad Sch, Dept Life & Nanopharmaceut Sci, 26 Kyungheedae Ro, Seoul 02447, South Korea.

MOLECULES, 2021; 26 (9):

Abstract

A series of PROTACs (PROteolysis-TArgeting Chimeras) consisting of bicalutamide analogs and thalidomides were designed, synthesized, and biologically ......

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