Long-term stimulation of toll-like receptor-2 and-4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages-MedSci.cn

Long-term stimulation of toll-like receptor-2 and-4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages

Ebert, R; Cumbana, R; Lehmann, C; Kutzner, L; Toewe, A; Ferreiros, N; Parnham, MJ; Schebb, NH; Steinhilber, D; Kahnt, AS

Kahnt, AS (corresponding author), Goethe Univ, Inst Pharmaceut Chem ZAFES, Max von Laue Str 9, D-60438 Frankfurt, Germany.

Abstract

Macrophage polarization switches during the course of inflammation along with the lipid mediators released. We investigated the lipid mediator formati......

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Long-term stimulation of toll-like receptor-2 and-4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages

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