Absorption, Distribution, Metabolism, and Excretion of [14C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro StudiesS

James, AD; Kulmatycki, K; Poller, B; Romeo, AA; Van Lier, JJ; Klein, K; Pearson, D

James, AD (通讯作者)，Novartis Pharm AG, Fabrikstr 14,WSJ 153-1-02-09, CH-4056 Basel, Switzerland.

DRUG METABOLISM AND DISPOSITION, 2023; 51 (7): 873

Abstract

Iptacopan (LNP023) is an oral, small-molecule, first-in-class, highly potent proximal complement inhibitor that specifically binds factor B and inhibi......

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