Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice-MedSci.cn

Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice

Wang, YF; Dong, ZQ; Yang, RJ; Zong, SJ; Wei, XC; Wang, CF; Guo, L; Sun, J; Li, HQ; Li, PC

Li, PC (通讯作者)，Shanxi Med Univ, Hosp 2, Shanxi Key Lab Bone & Soft Tissue Injury Repair, Dept Orthoped, Taiyuan, Shanxi, Peoples R China.

CALCIFIED TISSUE INTERNATIONAL, 2022; 111 (5): 519

Abstract

Indian hedgehog (Ihh) is an indispensable paracrine factor for proper tissue patterning, skeletogenesis, and cellular proliferation. Recent genetic st......

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Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice

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