Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Rujas, E; Cui, H; Sicard, T; Semesi, A; Julien, JP

Julien, JP (corresponding author), Hosp Sick Children, Res Inst, Program Mol Med, Toronto, ON M5G 0A4, Canada.; Julien, JP (corresponding author), Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.; Julien, JP (corresponding author), Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, and delivers a positive co-stimulatory signal to activated T cells upon bin......

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