Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

Lontos, K; Wang, YY; Colbert, M; Kumar, A; Joshi, S; Philbin, M; Wang, YP; Frisch, A; Lohmueller, J; Rivadeneira, DB; Delgoffe, GM

Delgoffe, GM (通讯作者),UPMC Hillman Canc Ctr, Tumor Microenvironm Ctr, Dept Immunol, 5117 Ctr Ave,2-26b HCC, Pittsburgh, PA 15232 USA.;Delgoffe, GM (通讯作者),Univ Pittsburgh, 5117 Ctr Ave,2-26b HCC, Pittsburgh, PA 15232 USA.

ONCOIMMUNOLOGY, 2022; 11 (1):

Abstract

The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages......

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