Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

Deshpande, D; Agarwal, N; Fleming, T; Gaveriaux-Ruff, C; Klose, CSN; Tappe-Theodor, A; Kuner, R; Nawroth, P

Nawroth, P (corresponding author), Univ Hosp Heidelberg, Dept Med & Clin Chem 1, INF 410, Heidelberg, Germany.; Nawroth, P (corresponding author), German Ctr Diabet Res DZD, Neuherberg, Germany.; Nawroth, P (corresponding author), Helmholtz Zentrum, Joint Heidelberg IDC Translat Diabet Program, D-85764 Neuherberg, Germany.

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protect......

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