Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency

Murata, T; Ito, G; Utsunomiya-Tate, N

Utsunomiya-Tate, N (通讯作者),Teikyo Univ, Fac Pharmaceut Sci, Dept Biomol Chem, 2-11-1 Kaga, Tokyo, Tokyo 1738605, Japan.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023; 654 (): 18

Abstract

Tau, a microtubule-binding protein, is a major component of neurofibrillary tangles in the brains of Alzheimer's disease patients. Tau aggregation fol......

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