Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus

Kang, SS; Liu, X; Ahn, EH; Xiang, J; Manfredsson, FP; Yang, XF; Luo, HR; Liles, LC; Weinshenker, D; Ye, KQ

Ye, KQ (corresponding author), 615 Michael St,Whitehead Bldg,Room 141, Atlanta, GA 30322 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2020; 130 (1): 422

Abstract

Aberrant Tau inclusions in the locus coeruleus (LC) are the earliest detectable Alzheimer's disease-like (AD-like) neuropathology in the human brain. ......

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