Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Kurokawa, C; Geekiyanage, H; Allen, C; Iankov, I; Schroeder, M; Carlson, B; Bakken, K; Sarkaria, J; Ecsedy, JA; D'Assoro, A; Friday, B; Galanis, E

Galanis, E (reprint author), Mayo Clin, Dept Mol Med, 200 First St SW, Rochester, MN 55905 USA.; Galanis, E (reprint author), Mayo Clin, Dept Oncol, 200 First St SW, Rochester, MN 55905 USA.

JOURNAL OF NEURO-ONCOLOGY, 2017; 131 (1): 41

Abstract

Aurora A kinase (AURKA), a member of the serine/threonine kinase family, plays a critical role in cell division, and it is widely overexpressed in a v......

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