GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion

Gandasi, NR; Gao, R; Kothegala, L; Pearce, A; Santos, C; Acreman, S; Basco, D; Benrick, A; Chibalina, MV; Clark, A; Guida, C; Harris, M; Johnson, PRV; Knudsen, JG; Ma, JF; Miranda, C; Shigeto, M; Tarasov, AI; Yeung, HY; Thorens, B; Asterholm, IW; Zhang, Q; Ramracheya, R; Ladds, G; Rorsman, P

Rorsman, P (通讯作者),Univ Gothenburg, Unit Metab Physiol, Inst Neurosci & Physiol, Dept Physiol,Sahlgrenska Acad, Gothenburg, Sweden.;Rorsman, P (通讯作者),Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Rorsman, P (通讯作者),Churchill Hosp, Oxford Natl Inst, Hlth Res Biomed Res Ctr, Oxford, England.;Rorsman, P (通讯作者),Ulster Univ, Sch Biomed Sci, Northern Ireland Ctr Stratified Med, Londonderry BT47 6SB, North Ireland.

DIABETOLOGIA, 2023; ():

Abstract

Aims/hypothesis Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventi......

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