Calicheamicin Antibody-Drug Conjugates with Improved Properties

Vollmar, BS; Frantz, C; Schutten, MM; Zhong, F; Rosario, GD; Go, MAT; Yu, SF; Leipold, DD; Kamath, AV; Ng, C; Xu, KY; Cruz-Chuh, JD; Kozak, KR; Chen, JH; Xu, ZJ; Wai, J; Adhikari, P; Erickson, HK; Dragovich, PS; Polson, AG; Pillow, TH

Pillow, TH (corresponding author), Genentech Inc, Res & Early Dev, San Francisco, CA 94080 USA.

MOLECULAR CANCER THERAPEUTICS, 2021; 20 (6): 1112

Abstract

Calicheamicin antibody-drug conjugates (ADCs) are effective therapeutics for leukemias with two recently approved in the United States: Mylotarg (gemt......

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