Physiologically-based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors

Ueno, T; Miyajima, Y; Landry, I; Lalovic, B; Schuck, E

Ueno, T (corresponding author), Eisai & Co Ltd, Drug Metab & Pharmacokinet, 5-1-3 Tokodai, Tsukuba, Ibaraki 3002635, Japan.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2021; 10 (5): 455

Abstract

Lemborexant, a recently approved dual orexin receptor antagonist for treatment of adults with insomnia, is eliminated primarily by cytochrome P450 (CY......

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