Identification of epigenome-wide DNA methylation differences between carriers of APOE epsilon 4 and APOE epsilon 2 alleles

Walker, RM; Vaher, K; Bermingham, ML; Morris, SW; Bretherick, AD; Zeng, YN; Rawlik, K; Amador, C; Campbell, A; Haley, CS; Hayward, C; Porteous, DJ; McIntosh, AM; Marioni, RE; Evans, KL

Walker, RM; Evans, KL (corresponding author), Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland.

GENOME MEDICINE, 2021; 13 (1):

Abstract

Background: The apolipoprotein E (APOE) epsilon 4 allele is the strongest genetic risk factor for late onset Alzheimer's disease, whilst the epsilon 2......

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