期刊： GENOME MEDICINE, 2022; 14 (1)
Background Lung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related death worldwide with metastases being the main cause of cancer-......
期刊： GENOME MEDICINE, 2022; 14 (1)
The taxonomic structure of microbial community sample is highly habitat-specific, making source tracking possible, allowing identification of the nich......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background: Pathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways. M......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Lack of functional evidence hampers variant interpretation, leaving a large proportion of individuals with a suspected Mendelian disorder w......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit fro......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background: Numerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (H......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background: The emergence of SARS-CoV-2 Omicron subvariants has raised questions regarding resistance to immunity by natural infection or immunization......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background: Identifying breast cancer patients with DNA repair pathway-related germline pathogenic variants (GPVs) is important for effectively employ......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of many cancers. However, the limited population that benefits f......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Natural killer (NK) cells are innate lymphoid cells that mediate antitumour and antiviral responses. However, very little is known about ho......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or c......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Understanding the host genetic architecture and viral immunity contributes to the development of effective vaccines and therapeutics for co......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Exome sequencing (ES) is becoming more widely available in prenatal diagnosis. However, data on its clinical utility and integration into c......
期刊： GENOME MEDICINE, 2022; 14 (1)
Background Ganciclovir (GCV) is widely used in solid organ and haematopoietic stem cell transplant patients for prophylaxis and treatment of cytomegal......
