Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity

Schmidt, H; Raj, T; O'Neill, TJ; Muschaweckh, A; Giesert, F; Negraschus, A; Hoefig, KP; Behrens, G; Esser, L; Baumann, C; Feederle, R; Plaza-Sirvent, C; Geerlof, A; Gewies, A; Isay, SE; Ruland, J; Schmitz, I; Wurst, W; Korn, T; Krappmann, D; Heissmeyer, V

Heissmeyer, V (通讯作者)，Ludwig Maximilians Univ Munchen, Inst Immunol, Med Fac, Biomed Ctr, D-82152 Martinsried, Germany.;Heissmeyer, V (通讯作者)，Helmholtz Zentrum Munchen, Mol Targets & Therapeut Ctr, German Res Ctr Environm Hlth, Res Unit Mol Immune Regulat, D-81337 Munich, Germany.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023; 120 (48):

Abstract

Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1TBM/TBM (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation a......

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