Preclinical and clinical characterization of the ROR gamma t inhibitor JNJ-61803534

Xue, XH; De Leon-Tabaldo, A; Luna-Roman, R; Castro, G; Albers, M; Schoetens, F; DePrimo, S; Devineni, D; Wilde, T; Goldberg, S; Hoffmann, T; Fourie, AM; Thurmond, RL

Xue, XH; Thurmond, RL (corresponding author), Janssen Res & Dev LLC, La Jolla, CA 92121 USA.

SCIENTIFIC REPORTS, 2021; 11 (1):

Abstract

The nuclear receptor retinoid-related orphan receptor gamma t (ROR gamma t) plays a critical role in driving Th17 cell differentiation and expansion, ......

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