Radiosynthesis and evaluation of 4-(6-[F-18]Fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2

Mori, W; Yamasaki, T; Hattori, Y; Zhang, YD; Kumata, K; Fujinaga, M; Hanyu, M; Nengaki, N; Zhang, H; Zhang, MR

Zhang, MR (corresponding author), Natl Inst Quantum & Radiol Sci & Technol, Dept Adv Nucl Med Sci, Natl Inst Radiol Sci, Inage Ku, Anagawa 4-9-1, Chiba 2638555, Japan.; Zhang, H (corresponding author), Zhejiang Univ, Sch Med, Hosp 2, Dept Nucl Med, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.; Zhang, H (corresponding author), Zhejiang Univ, Sch Med, Hosp 2, Med PET Ctr, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.

RSC MEDICINAL CHEMISTRY, 2020; 11 (6): 676

Abstract

Mutations that increase leucine-rich repeat kinase 2 (LRRK2) activity in the brain are associated with Parkinson's disease. Here, we synthesized a nov......

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