期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (5)
As a member of the cucurbit[n]uril family (where n denotes the number of glycoluril units), cucurbit[8]uril (CB[8]) possesses a large cavity volume an......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (8)
Two series of novel N-6 derivatives of 8-azapurine I and II were designed as antiplatelet agents. Series I and II were N-6 amino derivatives and N-6 h......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (4)
NIK is a key kinase required for the activation of alternative NF-kappa B signaling pathways. Overactivation of NIK in patients has been observed and ......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (7)
Globo H is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target for antitumor vaccine or cancer immunotherapies. However,......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (7)
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a typical survival time between three to five years. Two drugs, pirfeni......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (8)
A series of combretastatin A-4 (CA-4) sulfamate derivatives were synthesized and their structure-activity relationship on tubulin, arylsulfatase and t......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (7)
Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still spreading at an alarming rate and has caused huge loss of life an......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (4)
As serious global drug resistance motivated the exploration of new structural drugs, we developed a type of novel structural aloe-emodin azoles as pot......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (6)
With increasing pathogenic bacterial infection that is occurring worldwide, antibacterial therapy has become an important research field. There is gre......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (3)
The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been considered as potential targets for cancer therapy due to their role in r......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (8)
Targeted protein degradation represents a rapidly growing area in drug discovery and development. Moreover, small molecules that induce the targeted d......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (3)
An innovative pre-competitive virtual screening collaboration was engaged to validate and subsequently explore an imidazo[1,2-a]pyridine screening hit......
期刊： RSC MEDICINAL CHEMISTRY, 2021; 12 (2)
Background: mycobacterial cells contain complex mixtures of mycolic acid esters. These can be used as antigens recognised by antibodies in the serum o......
期刊： RSC MEDICINAL CHEMISTRY, 2020; 11 (6)
Mutations that increase leucine-rich repeat kinase 2 (LRRK2) activity in the brain are associated with Parkinson's disease. Here, we synthesized a nov......
期刊： RSC MEDICINAL CHEMISTRY, 2020; 11 (8)
Cancer is one of the most important problems that endanger human health. The number of cancer patients is increasing rapidly worldwide. Compared with ......
