The molecular basis of talin2 ' s high affinity toward beta 1-integrin

Yuan, YX; Li, LQ; Zhu, YY; Qi, L; Azizi, L; Hytonen, VP; Zhan, CG; Huang, C

Zhan, CG (reprint author), Univ Kentucky, Mol Modeling & Biopharm Ctr, Coll Pharm, Lexington, KY 40506 USA.; Huang, C (reprint author), Univ Kentucky, Markey Canc Ctr, Lexington, KY 40506 USA.; Huang, C (reprint author), Univ Kentucky, Dept Pharmacol & Nu

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

Talin interacts with beta-integrin tails and actin to control integrin activation, thus regulating focal adhesion dynamics and cell migration. There a......

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