Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation

Liu, TC; Kern, JT; Jain, U; Sonnek, NM; Xiong, SS; Simpson, KF; VanDussen, KL; Winkler, ES; Haritunians, T; Malique, A; Lu, QH; Sasaki, Y; Storer, C; Diamond, MS; Head, RD; McGovern, DPB; Stappenbeck, TS

Liu, TC; Stappenbeck, TS (corresponding author), Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA.; Stappenbeck, TS (corresponding author), Cleveland Clin, Dept Inflammat & Immun, Lerner Res Inst, Cleveland, OH 44195 USA.

CELL HOST & MICROBE, 2021; 29 (6): 988

Abstract

Intestinal Paneth cells modulate innate immunity and infection. In Crohn's disease, genetic mutations together with environmental triggers can disable......

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