Independent APOE4 knock-in mouse models display reduced brain APOE protein, altered neuroinflammation, and simplification of dendritic spines

Sepulveda, J; Luo, N; Nelson, M; Ng, CAS; Rebeck, GW

Rebeck, GW (通讯作者),Georgetown Univ, Dept Neurosci, Med Ctr, New Res Bldg,Room WP-15,3970 Reservoir Rd NW, Washington, DC 20007 USA.

JOURNAL OF NEUROCHEMISTRY, 2022; 163 (3): 247

Abstract

APOE is an immunomodulator in the brain and the major genetic risk factor for late-onset Alzheimer's disease ( AD). Targeted replacement APOE mice ( A......

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