Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Muhammad, RN; Sallam, N; El-Abhar, HS

Muhammad, RN (corresponding author), Cairo Univ, Dept Pharmacol & Toxicol, Fac Pharm, Cairo 11562, Egypt.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

5-Fluorouracil (5-FU) is used in the treatment of different solid tumors; however, its use is associated with rare, but serious cardiotoxicity. Nevert......

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