Grb2 binding induces phosphorylation-independent activation of Shp2

Lin, CCA; Wieteska, L; Suen, KM; Kalverda, AP; Ahmed, Z; Ladbury, JE

Lin, CCA; Ladbury, JE (corresponding author), Univ Leeds, Sch Mol & Cellular Biol, Leeds, W Yorkshire, England.; Lin, CCA; Ladbury, JE (corresponding author), Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds, W Yorkshire, England.; Ladbury, JE (corresponding author), Indian Inst Technol, Dept Chem, Mumbai, Maharashtra, India.

COMMUNICATIONS BIOLOGY, 2021; 4 (1):

Abstract

The regulation of phosphatase activity is fundamental to the control of intracellular signalling and in particular the tyrosine kinase-mediated mitoge......

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