GRB2 enforces homology-directed repair initiation by MRE11

Ye, Z; Xu, SF; Shi, Y; Bacolla, A; Syed, A; Moiani, D; Tsai, CL; Shen, Q; Peng, G; Leonard, PG; Jones, DE; Wang, B; Tainer, JA; Ahmed, Z

Tainer, JA; Ahmed, Z (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA.

SCIENCE ADVANCES, 2021; 7 (32):

Abstract

DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here......

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