ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16(INK4a) levels

Hao, X; Shiromoto, Y; Sakurai, M; Towers, M; Zhang, Q; Wu, S; Havas, A; Wang, L; Berger, S; Adams, PD; Tian, B; Nishikura, K; Kossenkov, AV; Liu, PY; Zhang, RG

Liu, PY; Zhang, RG (通讯作者)，Wistar Inst Anat & Biol, Immunol Microenvironm & Metastasis Program, 3601 Spruce St, Philadelphia, PA 19104 USA.;Liu, PY (通讯作者)，Fudan Univ, Zhangjiang Fudan Int Innovat Ctr, Human Phenome Inst, Shanghai, Peoples R China.

NATURE CELL BIOLOGY, 2022; 24 (8): 1202

Abstract

Cellular senescence plays a causal role in ageing and, in mice, depletion of p16(INK4a)-expressing senescent cells delays ageing-associated disorders(......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索