Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, V; Stoimenov, I; Mateus, A; Sjoberg, E; Svensson, R; Gustavsson, AL; Johansson, L; Ng, A; O'Brien, C; Giannakis, M; Artursson, P; Nygren, P; Cheong, I; Sjoblom, T

Sjoblom, T (corresponding author), Uppsala Univ, Sci Life Lab, Dept Immunol Genet & Pathol, SE-75185 Uppsala, Sweden.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygo......

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