Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Haake, M; Haack, B; Schäfer, T; Harter, PN; Mattavelli, G; Eiring, P; Vashist, N; Wedekink, F; Genssler, S; Fischer, B; Dahlhoff, J; Mokhtari, F; Kuzkina, A; Welters, MJP; Benz, TM; Sorger, L; Thiemann, V; Almanzar, G; Selle, M; Thein, K; Späth, J; Gonzalez, MC; Reitinger, C; Ipsen-Escobedo, A; Wistuba-Hamprecht, K; Eichler, K; Filipski, K; Zeiner, PS; Beschorner, R; Goedemans, R; Gogolla, FH; Hackl, H; Rooswinkel, RW; Thiem, A; Roche, PR; Joshi, H; Pühringer, D; Wöckel, A; Diessner, JE; Rüdiger, M; Leo, E; Cheng, PF; Levesque, MP; Goebeler, M; Sauer, M; Nimmerjahn, F; Schuberth-Wagner, C; von Felten, S; Mittelbronn, M; Mehling, M; Beilhack, A; van der Burg, SH; Riedel, A; Weide, B; Dummer, R; Wischhusen, J

Wischhusen, J (通讯作者),Univ Hosp Wurzburg, Dept Gynecol, Wurzburg, Germany.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Ac......

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