The HIF-1 alpha antisense long non-coding RNA drives a positive feedback loop of HIF-1 alpha mediated transactivation and glycolysis

Zheng, F; Chen, JN; Zhang, XQ; Wang, ZF; Chen, JW; Lin, XR; Huang, HY; Fu, WK; Liang, J; Wu, W; Li, B; Yao, HR; Hu, H; Song, EW

Hu, H; Song, EW (corresponding author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.; Song, EW (corresponding author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510120, Peoples R China.; Hu, H (corresponding author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Oncol, Guangzhou 510120, Peoples R China.; Song, EW (corresponding author), Bioland Lab, Guangzhou 510005, Peoples R China.; Song,

NATURE COMMUNICATIONS, 2021; 12 (1):

Abstract

Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1 alpha anti-sense lncRNA......

Full Text Link