Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates

Gyparaki, MT; Arab, A; Sorokina, EM; Santiago-Ruiz, AN; Bohrer, CH; Xiao, J; Lakadamyali, M

Lakadamyali, M (corresponding author), Univ Penn, Perelman Sch Med, Dept Physiol, Philadelphia, PA 19104 USA.; Lakadamyali, M (corresponding author), Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (19):

Abstract

Tau is a microtubule-associated protein, which promotes neuronal microtubule assembly and stability. Accumulation of tau into insoluble aggregates kno......

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