DGK zeta exerts greater control than DGK alpha over CD8(+) T cell activity and tumor inhibition

Gu, JC; Wang, C; Cao, C; Huang, JW; Holzhauer, S; Desilva, H; Wesley, EM; Evans, DB; Benci, J; Wichroski, M; Wee, S; Riese, MJ

Wichroski, M (corresponding author), Bristol Myers Squibb, Oncol Discovery, Princeton, NJ 08543 USA.

ONCOIMMUNOLOGY, 2021; 10 (1):

Abstract

Two isoforms of diacylglycerol kinases (DGKs), DGK alpha and DGK zeta, are primarily responsible for terminating DAG-mediated activation of Ras and PK......

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